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1

Evaluation of OptiFlow™-MS/MS for bioanalysis of pharmaceutical drugs and metabolites

Barricklow, Jason, Tweed, Joseph, Holliman, Christopher L, Ramanathan, Ragu

Journal:

Year:

2020

Language:

english

File:

PDF, 756 KB

english, 2020

2

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Applications of Quadrupole Time-of-Flight Mass Spectrometry in Reactive Metabolite Screening

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 5.02 MB

english, 2008

3

It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS

Ragu Ramanathan, Mohammed Jemal, Suma Ramagiri, Yuan-Qing Xia, W. Griffith Humpreys, Timothy Olah, Walter A. Korfmacher

Journal:

Journal of Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 326 KB

english, 2011

4

Distinguishing N-oxide and hydroxyl compounds: impact of heated capillary/heated ion transfer tube in inducing atmospheric pressure ionization source decompositions

Dilrukshi M. Peiris, Wing Lam, Steven Michael, Ragu Ramanathan

Journal:

Journal of Mass Spectrometry

Year:

2004

Language:

english

File:

PDF, 165 KB

english, 2004

5

Response Normalized Liquid Chromatography Nanospray Ionization Mass Spectrometry

Ragu Ramanathan, Ruyun Zhong, Neil Blumenkrantz, Swapan K. Chowdhury, Kevin B. Alton

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2007

Language:

english

File:

PDF, 403 KB

english, 2007

6

Quantitative determination of hippuric and benzoic acids in urine by LC–MS/MS using surrogate standards

Natalia Penner, Ragu Ramanathan, Joanna Zgoda-Pols, Swapan Chowdhury

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2010

Language:

english

File:

PDF, 1.28 MB

english, 2010

7

Comparison of heterogeneous and homogeneous radioactivity flow detectors for simultaneous profiling and LC-MS/MS characterization of metabolites

Laura A Egnash, Ragu Ramanathan

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2002

Language:

english

File:

PDF, 541 KB

english, 2002

8

Application of semi-automated metabolite identification software in the drug discovery process for rapid identification of metabolites and the cytochrome P450 enzymes responsible for their formation

Ragu Ramanathan, Donald L. McKenzie, Meera Tugnait, Kristen Siebenaler

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2002

Language:

english

File:

PDF, 184 KB

english, 2002

9

In electrospray ionization source hydrogen/deuterium exchange LC-MS and LC-MS/MS for characterization of metabolites

Wing Lam, Ragu Ramanathan

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2002

Language:

english

File:

PDF, 299 KB

english, 2002

10

A low flow ionization technique to integrate quantitative and qualitative small molecule bioanalysis

Ragu Ramanathan, Nirmala Raghavan, S. Nilgun Comezoglu, W. Griffith Humphreys

Journal:

International Journal of Mass Spectrometry

Year:

2011

Language:

english

File:

PDF, 852 KB

english, 2011

11

Preface to the 2013 Special Focus Issue of Bioanalysis on high-resolution MS

Korfmacher, Walter, Ramanathan, Ragu

Journal:

Year:

2013

Language:

english

File:

PDF, 908 KB

english, 2013

12

Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MS

Ranasinghe, Asoka, Ramanathan, Ragu, Jemal, Mohammed, D’Arienzo, Celia J, Humphreys, W Griffith, Olah, Timothy V

Journal:

Year:

2012

Language:

english

File:

PDF, 2.29 MB

english, 2012

13

The emergence of high-resolution MS as the premier analytical tool in the pharmaceutical bioanalysis arena

Ramanathan, Ragu, Korfmacher, Walter

Journal:

Year:

2012

Language:

english

File:

PDF, 886 KB

english, 2012

14

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || LC-MS Methods with Hydrogen/Deuterium Exchange for Identification of Hydroxylamine, N-Oxide, and Hydroxylated Analogs of Desloratadine

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 1.26 MB

english, 2008

15

Metabolism of Loratadine and Further Characterization of Its In Vitro Metabolites

Ghosal, Anima, Gupta, Samir, Ramanathan, Ragu, Yuan, Yuan, Lu, Xiaowen, Su, Ai, Alvarez, Narciso, Zbaida, Shmuel, Chowdhury, Swapan, Alton, Kevin

Journal:

Drug Metabolism Letters

Year:

2009

Language:

english

File:

PDF, 686 KB

english, 2009

16

Conference Report: Inaugural Applied Pharmaceutical Analysis: India 2010 Conference

Ramanathan, Ragu, Chaudhary, Ajai

Journal:

Year:

2010

Language:

english

File:

PDF, 370 KB

english, 2010

17

Novel MS solutions inspired by MIST

Ramanathan, Ragu, Josephs, Jonathan L, Jemal, Mohammed, Arnold, Mark, Humphreys, W Griffith

Journal:

Year:

2010

Language:

english

File:

PDF, 5.79 MB

english, 2010

18

Unconjugated payload quantification and DAR characterization of antibody–drug conjugates using high-resolution MS

Grafmuller, Leanne, Wei, Cong, Ramanathan, Ragu, Barletta, Frank, Steenwyk, Rick, Tweed, Joseph

Journal:

Year:

2016

Language:

english

File:

PDF, 1.70 MB

english, 2016

19

Advances in high-resolution MS and hepatocyte models solve a long-standing metabolism challenge: the loratadine story

Aratyn-Schaus, Yvonne, Ramanathan, Ragu

Journal:

Year:

2016

Language:

english

File:

PDF, 4.23 MB

english, 2016

20

HRMS in DMPK

Korfmacher, Walter, Ramanathan, Ragu

Journal:

Year:

2016

Language:

english

File:

PDF, 977 KB

english, 2016

21

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || High-Resolution LC-MS-Based Mass Defect Filter Approach: Basic Concept and Application in Metabolite Detection

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 2.33 MB

english, 2008

22

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Desorption Ionization Techniques for Quantitative Analysis of Drug Molecules

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 2.11 MB

english, 2008

23

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Turbulent-Flow LC-MS: Applications for Accelerating Pharmacokinetic Profiling and Metabolite Identification

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 1.48 MB

english, 2008

24

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Changing Role of FTMS in Drug Metabolism

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 1.67 MB

english, 2008

25

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Applications of High-Sensitivity Mass Spectrometry and Radioactivity Detection Techniques in Drug Metabolism Studies

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 1.48 MB

english, 2008

26

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Quantitative Bioanalysis in Drug Discovery and Development: Principles and Applications

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 1.31 MB

english, 2008

27

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Quadrupole, Triple-Quadrupole, and Hybrid Linear Ion Trap Mass Spectrometers for Metabolite Analysis

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 4.70 MB

english, 2008

28

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || MALDI Imaging Mass Spectrometry for Direct Tissue Analysis of Pharmaceuticals

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 1.80 MB

english, 2008

29

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Online Electrochemical-LC-MS Techniques for Profiling and Characterizing Metabolites and Degradants

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 1.63 MB

english, 2008

30

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Evolving Role of Mass Spectrometry in Drug Discovery and Development

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 8.93 MB

english, 2008

31

HRMS or HRAMS?

Ramanathan, Ragu, Korfmacher, Walter

Journal:

Year:

2016

Language:

english

File:

PDF, 916 KB

english, 2016

32

A highly selective and sensitive LC–MS/HRMS assay for quantifying coproporphyrins as organic anion-transporting peptide biomarkers

Ramanathan, Ragu, King-Ahmad, Amanda J., Holliman, Christopher L, Rodrigues, A David

Journal:

Year:

2017

Language:

english

File:

PDF, 1.30 MB

english, 2017

33

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Index

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 140 KB

english, 2008

34

Mass Spectrometry in Drug Metabolism and Pharmacokinetics (Ramanathan/Drug Metabolism and Pharmacokinetics) || Frontmatter

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 236 KB

english, 2008

35

A multiplex HRMS assay for quantifying selected human plasma bile acids as candidate OATP biomarkers

Rago, Brian, Tierney, Brendan, Rodrigues, A David, L Holliman, Christopher, Ramanathan, Ragu

Journal:

Year:

2018

Language:

english

File:

PDF, 929 KB

english, 2018

36

A fully automated and validated human plasma LC–MS/MS assay for endogenous OATP biomarkers coproporphyrin-I and coproporphyrin-III

King-Ahmad, Amanda, Clemens, Sara, Ramanathan, Ragu, Zhang, Yanhua, Raha, Nancy, Zhang, Yizhong, Holliman, Christopher, Rodrigues, A David, Li, Fumin

Journal:

Year:

2018

Language:

english

File:

PDF, 633 KB

english, 2018

37

HPLC–high-resolution mass spectrometry with polarity switching for increasing throughput of human in vitro cocktail drug–drug interaction assay

Ramanathan, Ragu, Ghosal, Anima, Ramanathan, Lakshmi, Comstock, Kate, Shen, Helen, Ramanathan, Dil

Journal:

Year:

2018

Language:

english

File:

PDF, 1.90 MB

english, 2018

38

Novel LC–MS assays impacting CYP and transporter drug–drug interaction evaluations

Ramanathan, Ragu

Journal:

Year:

2018

Language:

english

File:

PDF, 177 KB

english, 2018

39

LC–MS/MS assay for N 1 -methylnicotinamide in humans, an endogenous probe for renal transporters

Luo, Lina, Kay, Jared, Zhang, Jenny, Holliman, Christopher L, Rodrigues, A David, Dowty, Martin, Banfield, Christopher, Ramanathan, Ragu

Journal:

Year:

2018

Language:

english

File:

PDF, 984 KB

english, 2018

40

Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs

Mori, Daiki, Kimoto, Emi, Rago, Brian, Kondo, Yusuke, King‐Ahmad, Amanda, Ramanathan, Ragu, Wood, Linda S., Johnson, Jillian G., Le, Vu H., Vourvahis, Manoli, Rodrigues, A. David, Muto, Chieko, Furiha

Journal:

Clinical Pharmacology & Therapeutics

Year:

2019

Language:

english

File:

PDF, 885 KB

english, 2019

41

Dose‐Dependent Inhibition of OATP1B by Rifampicin in Healthy Volunteers: Comprehensive Evaluation of Candidate Biomarkers and OATP1B Probe Drugs

Mori, Daiki, Kimoto, Emi, Rago, Brian, Kondo, Yusuke, King‐Ahmad, Amanda, Ramanathan, Ragu, Wood, Linda S., Johnson, Jillian G., Le, Vu H., Vourvahis, Manoli, Rodrigues, A. David, Muto, Chieko, Furiha

Journal:

Clinical Pharmacology & Therapeutics

Year:

2019

File:

PDF, 885 KB

2019

42

Mass Spectrometry in Drug Metabolism and Pharmacokinetics ||

Ramanathan, Ragu

Year:

2008

Language:

english

File:

PDF, 33.44 MB

english, 2008

43

Evaluation of OptiFlow™-MS/MS for bioanalysis of pharmaceutical drugs and metabolites

Barricklow, Jason, Tweed, Joseph, Holliman, Christopher L, Ramanathan, Ragu

Journal:

Year:

2020

File:

PDF, 756 KB

2020

44

A Multiplexed HILIC-MS/HRMS Assay for the Assessment of Transporter Inhibition Biomarkers in Phase I Clinical Trials: Isobutyryl-Carnitine as an Organic Cation Transporter (OCT1) Biomarker

Luo, Lina, Ramanathan, Ragu, Horlbogen, Lauren, Mathialagan, Sumathy, Costales, Chester, Vourvahis, Manoli, Holliman, Christopher L., Rodrigues, A. David

Journal:

Analytical Chemistry

Year:

2020

File:

PDF, 468 KB

2020

45

P231 - Study to assess the food effect on plasma levels of emerging endogenous biomarkers of transporter mediated drug-drug interactions

King-Ahmad, Amanda, Rago, Brian, Luo, Lina, Rodrigues, A. David, Ramanathan, Ragu

Journal:

Drug Metabolism and Pharmacokinetics

Year:

2020

File:

PDF, 41 KB

2020

46

Identification of appropriate endogenous biomarker for risk assessment of multidrug and toxin extrusion proteinâmediated drugâdrug interactions in healthy volunteers

Miyake, Takeshi, Kimoto, Emi, Luo, Lina, Mathialagan, Sumathy, Horlbogen, Lauren M., Ramanathan, Ragu, Wood, Linda S., Johnson, Jillian G., Le, Vu H., Vourvahis, Manoli, Rodrigues, A. David, Muto, Chi

Journal:

Clinical Pharmacology & Therapeutics

Year:

2020

File:

PDF, 4.32 MB

2020

47

Identification of Glycochenodeoxycholate 3âOâGlucuronide and Glycodeoxycholate 3âOâGlucuronide as Highly Sensitive and Specific OATP1B1 Biomarkers

Neuvonen, Mikko, Hirvensalo, PÃ¤ivi, Tornio, Aleksi, Rago, Brian, West, Mark, Lazzaro, Sarah, Mathialagan, Sumathy, Varma, Manthena, Cerny, Matthew A., Costales, Chester, Ramanathan, Ragu, Rodrigues,

Journal:

Clinical Pharmacology & Therapeutics

Year:

2020

File:

PDF, 14.17 MB

2020